Mechanism of action
Antiplatelet agent.
Irreversible P2Y12 receptor antagonists (ADP receptor inhibitor) and hence inhibiting platelet activation and aggregation.
Requires 2 steps of bioactivation.
Indications and dose
Side-effects
Bleeding
GI upset
Pruritus
Hypersensitivity (allergy, SJS, TEN, Erythema multidorme)
Thrombotic Thrombocytopenic Purpura
Agranulocytosis
Pharmacokinetics
Onset of action: 2-6 hours
Offset of action: 3-10 days
Metabolism: Hepatic first pass using carboxylesterase 1 to an inactive carboxylic acid metabolite
Excretion: Urine and Feces (approximately 50% each)
Medicinal forms
1 tablet = 75 mg
References
- https://go.drugbank.com/drugs/DB00758
- https://next.amboss.com/us/article/Um0bUg?q=clopidogrel#Zb288dda860ff65493b01ea10fbf1e10c
- https://online.epocrates.com/drugs/1111/clopidogrel?MultiBrandAlert=true
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020839s044lbl.pdf
