Mechanism of action
Antiplatelet agent.
Reversible P2Y12 receptor antagonists (ADP receptor inhibitor) and hence inhibiting platelet activation and aggregation but is not a prodrug like clopidogrel.
Indications and dose
Side-effects
Bradycardia
Bleeding
Pruritus
Hypersensitivity (allergy, SJS, TEN, Erythema multidorme)
Thrombotic Thrombocytopenic Purpura
Agranulocytosis
Pharmacokinetics
Onset of action:Within 30 minutes
Brand: Brilinta, Brilique
Metabolism: Hepatic first pass using CYP450: 3A4
Half-life of elimination: 8-12 hours
Excretion: Feces 58%, 26% urine
Directions for administration
PO tablet
Medicinal forms
1 tablet = 60, 90 mg
References
- https://www.sciencedirect.com/topics/neuroscience/ticagrelor#:~:text=The%20onset%20of%20action%20of,of%208%20to%2012%20hours.
- https://next.amboss.com/us/article/Um0bUg?q=clopidogrel#Zb288dda860ff65493b01ea10fbf1e10c
- https://online.epocrates.com/drugs/614607/Brilinta/Pharmacology
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020839s044lbl.pdf
