Atracurium (Tracrium)
Mechanism of action
Non-depolarising neuromuscular blocker (intermediate acting).
Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate.
Indications and dose
Pharmacokinetics
Onset of action: 2–3 min
Duration of action: 15–35 min.
Half-life of elimination: 20 min
Metabolism: Hofmann elimination, non-specific plasma esterases
Elimination: liver, kidney
Directions for administration
Administer intravenously
Medicinal forms
Solution for injection/Infusion (10 mg/ml)
1 vial = 2.5 ml (25 mg) / 5 ml (50 mg) / 25 ml (250 mg)
Side-effects
Transient hypotension
Rash
Bronchospasm
Reversal
Rapid reversal of atracurium is achieved by anticholinesterase agents.
See more about it in Neostigmine list.
References
