Cisatracurium (Nimbex)
Mechanism of action
Non-depolarising neuromuscular blocker (intermediate acting).
Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate.
Indications and dose
Pharmacokinetics
Onset of action: 3–5 min
Duration of action: 30–60 min
Half-life of elimination: 22–29 min
Metabolism: Hofmann elimination, non-specific plasma esterases
Elimination: Liver, kidneys
Directions for administration
Administer intravenously
Medicinal forms
Solution for injection/Infusion (2 mg/ml)
1 vial = 2.5 ml (5 mg) / 5 ml (10 mg) / 10 ml (20 mg) / 25 ml (50 mg)
Side-effects
Hypotension
Bradycardia
Rash, flushing
Bronchospasm
Reversal
Rapid reversal of cisatracurium is achieved by anticholinesterase agents.
See more about it in Neostigmine list.
References
