Antiplatelet agent.
Irreversible P2Y12 receptor antagonists (ADP receptor inhibitor) and hence inhibiting platelet activation and aggregation.
Requires 2 steps of bioactivation.
Bleeding
GI upset
Pruritus
Hypersensitivity (allergy, SJS, TEN, Erythema multidorme)
Thrombotic Thrombocytopenic Purpura
Agranulocytosis
Onset of action: 2-6 hours
Offset of action: 3-10 days
Metabolism: Hepatic first pass using carboxylesterase 1 to an inactive carboxylic acid metabolite
Excretion: Urine and Feces (approximately 50% each)
1 tablet = 75 mg
References