Mechanism of action
Anti-inflammatory agent.
Intracellular disruption of tubulin leads to reduce of depolymerisation of microtubules, thus reduced cell motility and decreased migration of neutrophils.
Secondly colchicine causes destruction of the inflammasome complex inside of the monocytes and neutrophils and interferes with many other pathways important in the process of inflammation.
Indications and dose
Pharmacokinetics
Onset of action: 12 hours
Half-life of elimination: 20–40 hours
Metabolism: Hepatic
Elimination: Liver, Kidneys (10–20 %)
Directions for administration
Swallow tablet with a glass of water.
Reduce the dose by 50 % in patients with renal impairment.
Medicinal forms
Tablets – 500 µg
Side-effects
Diarrhoea, Nausea, Vomiting
Bone marrow depression
Loss of hair
Rash
Peripheral neuropathy
Myopathy
References
