Diclofenac (Voltarol, Voltaren, Akis)
Mechanism of action
NSAID - Inhibits cyclooxygenase 1 and 2 which results in block of production of prostaglandins, normally involved in the mechanism of inflammation and pain signalling.
Indications and dose
Pharmacokinetics
Onset of action:
- Immediate release pills: 15 minutes
- Prolonged release pills: 1.5–2 hours to peak concentration
Duration of action:
- Immediate release pills: 8 hours
- Prolonged release pills: up to 24 hours
Half-life of elimination: 3 hours
Metabolism: Hepatic (significant first-pass effect)
Elimination: Kidneys (60 %), liver
Directions for administration
Can be administered perorally, intramuscularly, subcutaneously or by intravenous bolus injection.
Medicinal forms
Pills:
- Immediate release pills– 25 mg, 50 mg,
- Prolonged release pills – 75 mg, 100 mg
Solution for injection/infusion (50 mg/ml, 75 mg/ml)
Side-effects
Rash, eczema, erythema, pruritus
Dermatitis bullous
Asthma
References
