Edoxaban

Mechanism of action

Anticoagulant (factor Xa inhibitor).

Inhibits activation of platelets and formation of fibrin clot by direct and reversible inhibition of factor Xa.

Indications and dose

Side-effects

Anaemia

Bleeding

Precautions

Contraindicated if CrCl < 15 ml/min.

Consider reducing the dose if co-administered with fungostatics, ATB (clarithromycin, erythromycin) or dronedarone.

Reversal agent

Andexanet alfa

Pharmacokinetics

Routes: Oral

Onset: 1-2 hours

Bioavailability: 62%

Metabolism: minimal

Half-life of elimination: 10-14 hours

Excretion: Urine

Medicinal forms

Tablet 30 mg and 60 mg.

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References

https://bnf.nice.org.uk/drugs/edoxaban/ 

https://www.uptodate.com/contents/edoxaban-drug-information?search=edoxaban&source=panel_search_result&selectedTitle=1~106&usage_type=panel&kp_tab=drug_general&display_rank=1#F26964813 

https://www.nice.org.uk/donotdo/do-not-withhold-anticoagulation-solely-because-the-person-is-at-risk-of-having-afall