Ibuprofen (Brufen, Caldolor)
Mechanism of action
NSAID - Inhibits cyclooxygenase 1 and 2 which results in block of production of prostaglandins, normally involved in the mechanism of inflammation and pain signalling.
Indications and dose
Pharmacokinetics
Onset of action: 30 minutes
Duration of action: 4–6 hours
Half-life of elimination: 2 hours
Metabolism: Hepatic
Elimination: Kidneys
Directions for administration
Infusion of ibuprofen should be administered over at least 30 minutes.
Medicinal forms
Pills – 200 mg, 400 mg
Solution for injection/infusion (100 mg/ml)
- 1 vial = 8 ml (800 mg)
Side-effects
Bleeding (inhibition of platelet aggregation)
Abdominal pain, nausea, vomiting
Ulcers
Nephrotoxicity
Hyperkalaemia
Proteinuria
Increased risk of thrombotic events
Fluid retention, oedema
Hypertension
Thrombocytopaenia, neutropenia, aplastic anaemia
Rash, pruritus
Asthma
References
