Mechanism of action
Mainly used as chronotropic agent => to increase the heart rate in severe bradycardia.
Sympathomimetic agonist acting on beta adrenoreceptors (beta1 > beta2) causing positive inotropy and chronotropy, increasing cardiac output, decreasing peripheral vascular resistance causing decrease in blood pressure.
Indications and dose
Side-effects
Arrhythmia
Tachycardia
Angina pectoris
Reflex hypotension
Headache
Pharmacokinetics
Onset: immediate
Duration: 10-15 minutes
Bioavailability: N/A
Metabolism: Hepatic, lungs, other (COMT)
Half-life of elimination: 2 minutes
Excretion: Urine
Directions for administration
For intravenous infusion dilute e.g. in 500 ml of 5% glucose or 0.9% sodium chloride.
Use e.g. 2 mg of Isoprenaline in 500 ml of solution => 7.5-60 ml/hour
Medicinal forms
1 vial = 0.2 mg (1 ml)
References
