Ivabradine (Corlanor, Procoralan)
Mechanism of action
Selectively inhibits If channels (“funny channels”) in sinoatrial node which prolongs diastolic depolarization of pacemaker and thus lowers heart rate and reduces myocardial oxygen demand, therefore angina pectoris symptoms.
Indications and dose
Pharmacokinetics
Onset of action: 1 hour
Duration of action: 11 hours effective half life
Half-life of elimination: 2 hours
Metabolism: Extensive gut and hepatic (CYP 3A4) metabolism
Elimination: Kidneys and liver equally
Directions for administration
Patients should not drink grapefruit juice while taking this medication.
Taking ivabradine with food is recommended as it increases its absorption by 20–30 %.
Pills are to be taken orally twice daily.
Medicinal forms
Pills – 5 mg, 7.5 mg
Side-effects
Bradycardia
Luminous phenomena (phosphenes)
1st degree AV block
Ventricular extrasystoles
Atrial fibrillation
Blurred vision
Headache, dizziness
References
