Mechanism of action
Cofactor for at least 300 enzymes involved in key biochemical processes like oxidative phosphorylation, glycolysis, or ATP metabolism.
Also plays important role in for example nerve function, muscle contraction or transmembrane ion flux.
Indications and dose
Medicinal forms
1 tablet of Magnesium lactate 500 mg = 50 mg of Magnesium
Solution for injection/infusion: 1 vial of Magnesium sulphate 10% => 100 mg/ml (10 ml=1 g), 20% = 200 mg/ml (10 ml=2 g)
Side-effects
Hypotension
Hypophosphatemia, hypertonic dehydration
Respiratory depression
Nausea, vomiting, drowsiness, confusion, coma
Hyporeflexia
Arrhythmias, cardiac arrest
Flushing
Muscle weakness
Reversal
In a case of symptomatic hypermagnesemia: administer calcium 100–200 mg IV over 5–10 min.
References
