Pancuronium (Pavulon)
Mechanism of action
Non-depolarising neuromuscular blocker (long acting).
Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate.
Indications and dose
Pharmacokinetics
Onset of action: 2–3 minutes
Duration of action: 45–60 minutes
Half-life of elimination: approx. 2 hours
Metabolism: Hepatic
Elimination: Kidneys
Directions for administration
For intravenous administration.
Not recommended to be given by infusion.
Medicinal forms
Solution for injection (2 mg/ml)
1 vial = 2 ml (4 mg)
Side-effects
Moderate tachycardia and increased cardiac output
Reversal
Rapid reversal of pancuronium is achieved by anticholinesterase agents.
See more about it in Neostigmine list.
References
