Pipecuronium (Arduan)
Mechanism of action
Non-depolarising neuromuscular blocker (long acting).
Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate.
Indications and dose
Pharmacokinetics
Onset of action: 2.5–3 min
Duration of action: 60–90min
Half-life of elimination: 1.7–2.3 hr
Metabolism: Hepatic
Elimination: Kidneys (80 %), liver (20 %)
Directions for administration
Administer intravenously
Medicinal forms
Solution for injection (2 mg/ml)
1 vial = 2 ml (4 mg)
Side-effects
Cardiac: transient hypotension, bradycardia, reduced cardiac output.
Malignant hyperthermia
Reversal
Rapid reversal of pipecuronium is achieved by anticholinesterase agents.
See more about it in Neostigmine list.
References
