Pregabalin (Lyrica)
Mechanism of action
Anticonvulsant, anxiolytic and analgesic medication.
Mechanism of action still not fully understood.
Binding to presynaptic voltage-gated calcium channels and modulation of the release of several excitatory neurotransmitters is probably responsible for the antiseizure and antinociceptive effects of pregabalin.
Indications and dose
Pharmacokinetics
Onset of action: 1.5 hours
Half-life of elimination: 6.3 hours
Metabolism: Less than 2 % of pregabalin is metabolized
Elimination: Kidneys (as unchanged drug)
Medicinal forms
Tablets – 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Side-effects
Dizziness, somnolence, headache
Increased appetite
Mood changes, confusion, irritability, decreased libido
Vomiting, nausea, diarrhoea
Ataxia, tremor, dysarthria, amnesia, attention disorders
Diplopia, blurred vision
Vertigo
References
