Propafenone (Rytmonorm, Propanorm)
Mechanism of action
- Blocks sodium channels on cardiomyocytes which leads to their reduced excitation. This reduces myocardial automaticity and slows down the impulse conduction as well as prolongs refractory period of cardiomyocytes.
- Also has a weak effect as beta-blocker which may be clinically significant in high doses.
Indications and dose
Pharmacokinetics
Onset of action:
- within 2–3 hours
- steady state after 3–4 days
Half-life of elimination: 2–10 hours (up to 32 hours for slow metabolizers)
Metabolism: Hepatic
Elimination: Kidneys
Directions for administration
Peroral: increase of dosage should be undertaken after at least three days of original treatment.
Medicinal forms
Pills – 150 mg, 225 mg, 300 mg
1 vial - 35 mg (10 ml)
Side-effects
Dizziness
Conduction disorders
Palpitations
Dysgeusia
Bradycardia, tachycardia, arrhythmia
Nausea, Vomiting
Abdominal and chest pain
Sleep disorders
References
Arythmol 150 mg Tablets - Summary of Product Characteristics (SmPC) - (emc) (medicines.org.uk)
