Mechanism of action
Reversal agent of heparin.
As a highly alkaline protein binds to strongly acidic heparin and forms stable salt, neutralising its anticoagulant effect.
Indications and dose
Side-effects
Non-cardiogenic pulmonary edema
Hypersensitivity reactions
Pharmacokinetics
Routes: Intravenous
Onset: 5 minutes
Half-life of elimination: 7 minutes
Directions for administration
For intravenous use do not exceed rate of 50 mg/10 minutes for hypotension + possible anticoagulant effect.
Medicinal forms
Solution for injection
1 vial = 25 ml (250 mg)
1 vial = 5 ml (50 mg)
References
