Mechanism of action
- Opioid analgesic (ultra-short duration of action)
- Analgesic properties are based mostly on its selective agonism to the μ-opioid receptor (MOR) which is crucial for transmission of information about pain throughout the central nervous system. These receptors are located mostly in brainstem and thalamus.
Indications and dose
Pharmacokinetics
Onset of action: rapid (about 1 minute)
Duration of action: 3–10 minutes after discontinuation
Half-life of elimination: 1–20 minutes
Metabolism: Nonspecific blood and tissue esterases
Elimination: Kidneys
Medicinal forms
Powder for Solution for Injection/Infusion – 1 mg, 2 mg, 5 mg
e.g. 2 mg ad 50 ml F1/1
Side-effects
Respiratory depression
Muscle rigidity
CNS depression
Cardiovascular depression (hypotension, bradycardia)
Serotonin syndrome
Nausea, vomiting
Seizures
Reversal
Rapid reversal may be achieved with Naloxone.
See more about it in Naloxone list.
References
