Mechanism of action
Anticoagulant (factor Xa inhibitor).
Inhibits activation of platelets and formation of fibrin clot by direct and reversible inhibition of factor Xa.
Indications and dose
Side-effects
Anaemia
Bleeding
Precautions
Must be taken with food.
Consider dose reduction in case of co-administration of dronedarone, chinidin, fungostatics or ritonavir.
Consult guidelines and literature about safety, suspending and restarting anticoagulants when performing invasive procedures.
Do not withhold anticoagulation solely due to risk of falls.
Reversal agent
Andexanet alfa
Pharmacokinetics
Routes: Oral
Onset: 2-4 hours
Bioavailability: 66-100% (increased with food)
Metabolism: Hepatic
Half-life of elimination: 5-9 hours (11-13 hours in elderly)
Excretion: Urine
Medicinal forms
Tablets - 2.5 mg, 10 mg, 15 mg and 20 mg
References
