Rocuronium (Esmeron, Zemuron)
Mechanism of action
Non-depolarising neuromuscular blocker (intermediate acting).
Blocks neuromuscular transmission by competitive inhibition of nicotinic acetylcholine receptors on the motor end-plate.
Is used as a paralytic in rapid sequence induction.
Indications and dose
Pharmacokinetics
Onset of action: 45–60 seconds
Duration of action: 20–35 minutes
Half-life of elimination: 73 minutes
Metabolism: Hepatic
Elimination: liver (75–90%) and kidney
Directions for administration
Administer intravenously
Medicinal forms
Solution for injection/infusion (10 mg/ml)
1 vial = 5 ml (50 mg)
Side-effects
Tachycardia
Hypotension
Bronchospasm
Rash
Reversal
Rapid reversal of rocuronium is achieved by Sugammadex.
Dosing varies for desired reversal effects:
- 2 mg/kg: reversal of shallow neuromuscular blockade
- 4 mg/kg: reversal of deeper blockade
- 16 mg/kg: immediate reversal following administration of single dose 1.2 mg/kg rocuronium
See more about it in Sugammadex list.
References
