Sugammadex (Bridion)
Mechanism of action
Selective Rocuronium (and Vecuronium) antagonist.
Forms very tight water-soluble complexes with free neuromuscular blockers rocuronium and vecuronium. This process creates a concentration gradient and facilitates diffusion of bound rocuronium/vecuronium from neuromuscular junction back to plasma.
Is used as a selective quick-acting rocuronium and vecuronium antagonist.
Indications and dose
Pharmacokinetics
Onset of action: 1.5–3 minutes
Duration of action: – 20-75 minutes
Half-life of elimination: 2 hours
Metabolism: Not metabolized
Elimination: Kidneys
Directions for administration
Administer rapidly (within 10 seconds) IV.
Medicinal forms
Solution for injection (100 mg/ml)
1 vial = 2 ml (200 mg) / 5 ml (500 mg)
Side-effects
Cough
Hypersensitivity reaction
Airway complications of anaesthesia
References
