Mechanism of action
Allosteric modulator and agonist of GABA receptors causing global depression of CNS resulting in sedative, hypnotic and antiseizure effects.
Indications and dose
Side-effects
Nausea
Hypotension
Headache
Drowsiness
Skin rash
Confusion and hallucination
Respiratory depression
Agranulocytosis
Stevens-Johnson syndrome
Liver injury
Megaloblastic anaemia
Barbiturate dependence
Contraindications
Cardiovascular instability and shock
Status asthmaticus
Pharmacokinetics
Onset of action: 30-45 seconds
Duration of action: 5-10 minutes
Bioavailability: N/A
Metabolism: Hepatic
Half-life of elimination: 5-26 hours
Excretion: Urine
Medicinal forms
Solution for injection
1 vial = 0.5 g or 1 g
References
- https://en.wikipedia.org/wiki/Barbiturate
- https://bnf.nice.org.uk/drugs/thiopental-sodium/
- https://www.uptodate.com/contents/thiopental-international-drug-information-concise?search=thiopental&source=panel_search_result&selectedTitle=1~50&usage_type=panel&kp_tab=drug_international&display_rank=1
- https://en.wikipedia.org/wiki/Sodium_thiopental
