Mechanism of action
Antipsychotic (benzamide derivative).
Antagonist of dopamine D2 and D3 receptors.
Indications and dose
Contraindications
Prolactinoma
Pheochromocytoma
Concomitant use of dopaminergic drugs (e.g. levodopa)
Side-effects
Hyperprolactinaemia
Insomnia
Fatigue
Vertigo
Neuroleptic malignant syndrome
Prolonged QT interval
Precautions
Avoid in patients with Parkinson’s disease.
Cautious use in patients with breast cancer due to effects of tiapride on prolactin levels.
Pharmacokinetics
Routes: Oral, Intravenous, Intramuscular (preferred parenteral route)
Onset of action: 30 minutes (intramuscular); 1 hour (oral)
Bioavailability: 75%
Metabolism: Minimal
Half-life of elimination: 3 hours
Excretion: Urine
Directions for administration
Tablets may be crushed.
Dilute in water for injections.
Medicinal forms
Tablet - 100 mg
1 drop = 5 mg
Solution for injection - 1 vial = 2 ml (100 mg)
References
