Vitamin K

Mechanism of action

Vitamin, reversal agent of warfarin.

Promotes liver synthesis of clotting factors (factor II, VII, IX, X), antagonising effect of warfarin.

Indications and dose

Side-effects

Infusion related reactions

Pharmacokinetics

Routes: Oral, Intravenous

Onset: 1-2 hours (IV), 6-10 hours (oral)

Duration: 24-48 hours (oral), 12-14 hours (intravenous)

Metabolism: Hepatic

Half-life of elimination: 

Excretion: Urine and facees

Directions for administration

For intravenous injection give in 5% glucose.

Medicinal forms

Oral solution - 1 drop (1 mg)

Solution for injection - 1 vial = 1 ml (10 mg)

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References

https://bnf.nice.org.uk/drugs/phytomenadione/ 

https://www.uptodate.com/contents/vitamin-k-phytonadione-phytomenadione-drug-information?search=phytonadione&source=panel_search_result&selectedTitle=1~148&usage_type=panel&kp_tab=drug_general&display_rank=1#F209747